Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11793 ...
Drug Name Niraparib
Molecular Weight 320.396
Molecular Formula C19H20N4O
CAS Number 1038915-60-4
SMILES NC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)[C@@H]1CCCNC1
External Links
DRUGBANK DB11793
PubChem Compound 24958200
PDR 24070

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 73.0 % 73 % DRUGBANK
C Max 804.0 ng/ml 804±403 ng/ml Oral single dose; DRUGBANK
T Max 3.0 h 3 h PO, oral; DRUGBANK
Clearance 16.2 L/h 16.2 L/h apparent clearance; tumor; patients; DRUGBANK
Volume of Distribution 1220.0 L 1220±1114 L Steady state volume of distribution; DRUGBANK
Half-life 36.0 h 36 h DRUGBANK
Eliminate Route 47.5 % 47.5 % Urinary excretion; Oral single dose; DRUGBANK
Eliminate Route 38.8 % 38.8 % Faeces excretion; Oral single dose; DRUGBANK
Protein Binding 83.0 % 83 % plasma proteins; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 300.0 mg/day 300 mg/day PO, oral qd Zejula niraparib PDR
Max dose for geriatric 300.0 mg/day 300 mg/day PO, oral qd Zejula niraparib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1