Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11760 ...
Drug Name Talazoparib
Molecular Weight 380.359
Molecular Formula C19H14F2N6O
CAS Number 1207456-01-6
SMILES CN1N=CN=C1[C@@H]1[C@H](NC2=C3C1=NNC(=O)C3=CC(F)=C2)C1=CC=C(F)C=C1
External Links
DRUGBANK DB11760
PubChem Compound 44819241
PDR 24257

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
T Max 1.5 h 1-2 h Capsule, PO, Oral; DRUGBANK
T Max 2.5 h 1-4 h PO, oral; high-fat meal; DRUGBANK
Clearance 6.5 L/h 6.45 L/h apparent clearance; PO, oral; RD, renal impairment, Renal disease，including uremia → ; DRUGBANK
Volume of Distribution 420.0 L 420.0 L Steady state volume of distribution; DRUGBANK
Half-life 90.0 h 90±58 h terminal half-life; Capsule, PO, Oral; DRUGBANK
Eliminate Route 64.7 % 64.7 % Urinary excretion; DRUGBANK
Eliminate Route 19.7 % 19.7 % Faeces excretion; DRUGBANK
Eliminate Route 35.3 % 35.32 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 2.7 % 2.67 % Faeces excretion; Unchanged drug; DRUGBANK
Protein Binding 74.0 % 74 % plasma proteins; Plasma Concentration → ; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 1.0 mg 1 mg PO, oral qd Talzenna talazopari PDR
Max dose for geriatric 1.0 mg 1 mg PO, oral qd Talzenna talazopari PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1