Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Boiling Point | 601.0 | ℃ | 601 | ℃ | DRUGBANK |
| Melting Point | 191.0 | ℃ | 189-193 | ℃ | DRUGBANK |
| Water Solubility | 0.5 | mg/L | 0.5 | μg/ml | DRUGBANK |
| pKa | 0.78 | - | 0.78 | - | FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 11100.0 | ng.h/ml | 11100.0 | ng.h/ml | DRUGBANK | AUC | 610.0 | ng.h/ml | 610.0 | ng.h/ml | Active metabolite; | DRUGBANK |
| C Max | 181.1 | ng/ml | 181.1 | ng/ml | DRUGBANK | C Max | 4.3 | ng/ml | 4.34 | ng/ml | Active metabolite; | DRUGBANK | C Max | 12.6 | ng/ml | 12.6 | ng/ml | Active metabolite; | DRUGBANK |
| T Max | 2.0 | h | 2 | h | DRUGBANK | T Max | 3.5 | h | 3.5 | h | Active metabolite; | DRUGBANK | T Max | 3.0 | h | 3 | h | Active metabolite; | DRUGBANK |
| Clearance | 5.1 | L/h | 4.1-6 | L/h | apparent clearance; | DRUGBANK |
| Volume of Distribution | 502.5 | L | 448-557 | L | Apparent volume of distribution; | DRUGBANK |
| Half-life | 66.5 | h | 64-69 | h | elimination half-life; | DRUGBANK |
| Toxicity LD50 | 300.0 | mg/kg | >300 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 17.6 | % | 17.6 | % | Urinary excretion; PO, oral; Male, men; Rattus, Rat; | DRUGBANK | Eliminate Route | 68.3 | % | 68.3 | % | Faeces excretion; PO, oral; Male, men; Rattus, Rat; | DRUGBANK | Eliminate Route | 1.6 | % | 1.62 | % | Faeces excretion; PO, oral; Male, men; Rattus, Rat; Unchanged drug; | DRUGBANK |
| Protein Binding | 98.0 | % | ~98 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1