Basic Information
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 86.0 | % | >86 | % | PO, oral; | DRUGBANK |
| T Max | 2.0 | h | 2 | h | PO, oral; | DRUGBANK |
| Metabolic | 83.0 | % | 83 | % | Liver metabolism; | DRUGBANK |
| Metabolic | 16.0 | % | 16 | % | Liver metabolism; | DRUGBANK |
| Metabolic | 1.0 | % | 1 | % | Liver metabolism; | DRUGBANK |
| Clearance | 14.0 | L/h | 14.0 | L/h | apparent clearance; | DRUGBANK |
| Clearance | 32.0 | L/h | 32.0 | L/h | apparent clearance; at steady state; | DRUGBANK |
| Volume of Distribution | 164.0 | L | 164.0 | L | Apparent volume of distribution; | DRUGBANK |
| Half-life | 3.5 | h | 3.5 | h | terminal half-life; | DRUGBANK |
| Eliminate Route | 47.0 | % | 47 | % | Faeces excretion; Oral single dose; | DRUGBANK |
| Eliminate Route | 47.0 | % | 47 | % | Urinary excretion; Oral single dose; | DRUGBANK |
| Eliminate Route | 5.0 | % | 5 | % | Faeces excretion; Oral single dose; Unchanged drug; | DRUGBANK |
| Eliminate Route | 2.0 | % | 2 | % | Urinary excretion; Oral single dose; Unchanged drug; | DRUGBANK |
| Protein Binding | 86.0 | % | 86 | % | plasma proteins; high protein binding; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 450.0 | mg/day | 450 | mg/day | PO, oral | Braftovi | encorafenib | PDR |
| Max dose for geriatric | 450.0 | mg/day | 450 | mg/day | PO, oral | Braftovi | encorafenib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1