Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11718 ...
Drug Name Encorafenib
Molecular Weight 540.01
Molecular Formula C22H27ClFN7O4S
CAS Number 1269440-17-6
SMILES COC(=O)N[C@@H](C)CNC1=NC=CC(=N1)C1=CN(N=C1C1=CC(Cl)=CC(NS(C)(=O)=O)=C1F)C(C)C
External Links
DRUGBANK DB11718
PubChem Compound 50922675
PDR 24220

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 86.0 % >86 % PO, oral; DRUGBANK
T Max 2.0 h 2 h PO, oral; DRUGBANK
Metabolic 83.0 % 83 % Liver metabolism; DRUGBANK
Metabolic 16.0 % 16 % Liver metabolism; DRUGBANK
Metabolic 1.0 % 1 % Liver metabolism; DRUGBANK
Clearance 14.0 L/h 14.0 L/h apparent clearance; DRUGBANK
Clearance 32.0 L/h 32.0 L/h apparent clearance; at steady state; DRUGBANK
Volume of Distribution 164.0 L 164.0 L Apparent volume of distribution; DRUGBANK
Half-life 3.5 h 3.5 h terminal half-life; DRUGBANK
Eliminate Route 47.0 % 47 % Faeces excretion; Oral single dose; DRUGBANK
Eliminate Route 47.0 % 47 % Urinary excretion; Oral single dose; DRUGBANK
Eliminate Route 5.0 % 5 % Faeces excretion; Oral single dose; Unchanged drug; DRUGBANK
Eliminate Route 2.0 % 2 % Urinary excretion; Oral single dose; Unchanged drug; DRUGBANK
Protein Binding 86.0 % 86 % plasma proteins; high protein binding; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 450.0 mg/day 450 mg/day PO, oral Braftovi encorafenib PDR
Max dose for geriatric 450.0 mg/day 450 mg/day PO, oral Braftovi encorafenib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1