Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 99.0 | - | 99.0 | - | https://www.medkoo.com/uploads/product/Tezacaftor__VX-661_/safety/MSDS-VX661.pdf |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 84500.0 | ng.h/ml | 84.5 | mcg.h/ml | combination drug use; | DRUGBANK |
| C Max | 5950.0 | ng/ml | 5.95 | mcg/ml | combination drug use; | DRUGBANK |
| T Max | 4.0 | h | 2-6 | h | combination drug use; | DRUGBANK |
| Clearance | 1.3 | L/h | 1.31 | L/h | apparent clearance; food; patients; | DRUGBANK |
| Volume of Distribution | 271.0 | L | 271.0 | L | Apparent volume of distribution; food; patients; | DRUGBANK |
| Half-life | 57.2 | h | ~57.2 | h | DRUGBANK | |
| Toxicity LD50 | 2000.0 | mg/kg | >2000 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 72.0 | % | <72 | % | Faeces excretion; PO, oral; Unchanged drug; | DRUGBANK | Eliminate Route | 1.0 | % | <1 | % | Urinary excretion; PO, oral; Unchanged drug; | DRUGBANK |
| Protein Binding | 99.0 | % | 99 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1