Basic Information

Drug ID DDPD11703 ...
Drug Name Acalabrutinib
Molecular Weight 465.517
Molecular Formula C26H23N7O2
CAS Number 1420477-60-6
SMILES CC#CC(=O)N1CCC[C@H]1C1=NC(=C2N1C=CN=C2N)C1=CC=C(C=C1)C(=O)NC1=CC=CC=N1
External Links
DRUGBANK DB11703
PubChem Compound 71226662

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.49 - 0.49 - ChemSpider

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 25.0 % 25 % DRUGBANK
T Max 0.75 h 0.75 h DRUGBANK
Clearance 159.0 L/h 159.0 L/h apparent clearance; PO, oral; DRUGBANK
Volume of Distribution 34.0 L 34.0 L Steady state volume of distribution; DRUGBANK
Half-life 0.90 h 0.9(0.6-2.8) h elimination half-life; Oral single dose; DRUGBANK
Eliminate Route 84.0 % 84 % Faeces excretion; Single dose; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 12.0 % 12 % Urinary excretion; Single dose; normal,healthy; human, homo sapiens; DRUGBANK
Protein Binding 97.5 % ~97.5 % plasma proteins; human, homo sapiens; DRUGBANK
Protein Binding 93.7 % 93.7 % human, homo sapiens; DRUGBANK
Protein Binding 41.1 % 41.1 % human, homo sapiens; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1