Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 229.0 | ℃ | 229±2 | ℃ | EMA Assessment Report |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 96.5 | % | 93-100 | % | DRUGBANK | |
| C Max | 76.5 | ng/ml | 16-137 | ng/ml | Oral single dose; fasting; | DRUGBANK |
| T Max | 0.95 | h | 0.6-1.3 | h | PO, oral; | DRUGBANK |
| Half-life | 2.5 | h | ~2.5 | h | elimination half-life; | DRUGBANK | Half-life | 4.0 | h | 4 | h | elimination half-life; | DRUGBANK |
| Toxicity LD50 | 25.0 | mg/kg | ~>25 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 100.0 | mg/kg | ~100 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 25.0 | mg/kg | ~25 | mg/kg | intravenous injection, IV; mouse; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 20.0 | mg/kg | 20.0 | mg/kg | Intraperitoneal, IP; mouse; | DRUGBANK | Toxicity LD50 | 35.0 | mg/kg | 35.0 | mg/kg | subcutaneous injection, SC; mouse; | DRUGBANK |
| Eliminate Route | 24.0 | % | >24 | % | Urinary excretion; PO, oral; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 30.0 | mg/dose | 30 | mg/dose | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for children | 100.0 | mg/day | 100 | mg/day | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for children | 50.0 | mg/day | 50 | mg/day | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for children | 15.0 | mg/dose | 15 | mg/dose | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for adolescents | 30.0 | mg/dose | 30 | mg/dose | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for adolescents | 100.0 | mg/day | 100 | mg/day | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for adolescents | 50.0 | mg/day | 50 | mg/day | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for adolescents | 15.0 | mg/dose | 15 | mg/dose | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for adults | 20.0 | mg/dose | 20 | mg/dose | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for adults | 80.0 | mg/day | 80 | mg/day | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for geriatric | 20.0 | mg/dose | 20 | mg/dose | PO, oral | Ruzurgi | amifampridine | PDR |
| Max dose for geriatric | 80.0 | mg/day | 80 | mg/day | PO, oral | Ruzurgi | amifampridine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1