Basic Information
| Drug ID | DDPD11611 |
|
| Drug Name | Lifitegrast | |
| Molecular Weight | 615.48 | |
| Molecular Formula | C29H24Cl2N2O7S | |
| CAS Number | 1025967-78-5 | |
| SMILES | CS(=O)(=O)C1=CC(C[C@H](NC(=O)C2=C(Cl)C3=C(CN(CC3)C(=O)C3=CC=C4C=COC4=C3)C=C2Cl)C(O)=O)=CC=C1 | |
| External Links | ||
| DRUGBANK | DB11611 | |
| PubChem Compound | 11965427 | |
| PDR | 3926 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 1.7 | ng/ml | 1.70 | ng/ml | DRUGBANK | C Max | 2.1 | ng/ml | 0.55-3.74 | ng/ml | different study; | DRUGBANK |
| T Max | 0.25 | h | 15 | min | DRUGBANK | |
| Protein Binding | 99.0 | % | ~99 | % | plasma proteins; human, homo sapiens; | DRUGBANK | Protein Binding | 96.5 | % | 95-98 | % | human, homo sapiens; | DRUGBANK | Protein Binding | 41.4 | % | 31.6-51.1 | % | human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 2.0 | drop/day | 2 | drop/day | ophthalmic administration | Xiidra | lifitegrast | PDR |
| Max dose for adults | 2.0 | drop/day | 2 | drop/day | ophthalmic administration | Xiidra | lifitegrast | PDR |
| Max dose for geriatric | 2.0 | drop/day | 2 | drop/day | ophthalmic administration | Xiidra | lifitegrast | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1