Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11591 ...
Drug Name Bilastine
Molecular Weight 463.622
Molecular Formula C28H37N3O3
CAS Number 202189-78-4
SMILES CCOCCN1C(=NC2=CC=CC=C12)C1CCN(CCC2=CC=C(C=C2)C(C)(C)C(O)=O)CC1
External Links
DRUGBANK DB11591
PubChem Compound 185460

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 61.0 % 61 % DRUGBANK
T Max 1.1 h 1.13 h DRUGBANK
Clearance 9.2 L/h 9.2 L/h Total clearance; DRUGBANK
Clearance 8.7 L/h 8.7 L/h Renal clearance; DRUGBANK
Clearance 0.17 L/h/kg 2.87 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.61 L/kg 0.61 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 14.5 h 14.5 h elimination half-life; DRUGBANK
Half-life 5.2 h 5.16 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity NOAEL 1200.0 mg/kg/day 1200.0 mg/kg/day Rattus, Rat; DRUGBANK
Toxicity NOAEL 125.0 mg/kg/day 125.0 mg/kg/day dog; DRUGBANK
Eliminate Route 66.5 % 66.5 % Faeces excretion; DRUGBANK
Eliminate Route 28.3 % 28.3 % Urinary excretion; DRUGBANK
Protein Binding 87.0 % 84-90 % plasma proteins; human, homo sapiens; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1