Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11586 ...
Drug Name Asunaprevir
Molecular Weight 748.286
Molecular Formula C35H46ClN5O9S
CAS Number 630420-16-5
SMILES COC1=CN=C(O[C@@H]2C[C@H](N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)C(=O)N[C@@]2(C[C@H]2C=C)C(=O)NS(=O)(=O)C2CC2)C2=C1C=CC(Cl)=C2
External Links
DRUGBANK DB11586
PubChem Compound 16076883

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 150.0 ℃ 145-155 ℃ 'MSDS
Water Solubility 50.0 mg/L <50 mg/L Australian Public Assessment

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 1887.0 ng.h/ml 1887.0 ng.h/ml DRUGBANK
Bioavailability 9.3 % 9.3 % DRUGBANK
C Max 572.0 ng/ml 572 ng/ml DRUGBANK
T Max 3.0 h 2-4 h DRUGBANK
Clearance 396.5 L/h 302-491 L/h Average clearance; PO, oral; DRUGBANK
Clearance 0.71 L/h/kg 11.78 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 194.0 L 194.0 L at steady state; DRUGBANK
Volume of Distribution 2.8 L/kg 2.77 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 17.5 h 15-20 h terminal half-life; DRUGBANK
Half-life 20.0 h 20 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 7.5 % 7.5 % Faeces excretion; Unchanged drug; DRUGBANK
Protein Binding 99.0 % >99 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1