Basic Information
| Drug ID | DDPD11581 |
|
| Drug Name | Venetoclax | |
| Molecular Weight | 868.45 | |
| Molecular Formula | C45H50ClN7O7S | |
| CAS Number | 1257044-40-8 | |
| SMILES | CC1(C)CCC(CN2CCN(CC2)C2=CC=C(C(=O)NS(=O)(=O)C3=CC=C(NCC4CCOCC4)C(=C3)[N+]([O-])=O)C(OC3=CN=C4NC=CC4=C3)=C2)=C(C1)C1=CC=C(Cl)C=C1 | |
| External Links | ||
| DRUGBANK | DB11581 | |
| PubChem Compound | 49846579 | |
| PDR | 3916 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 99.0 | - | 99.0 | - | MSDS |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 32800.0 | ng.h/ml | 32.8±16.9 | ug.h/ml | PO, oral; low fat meal; | DRUGBANK |
| C Max | 2100.0 | ng/ml | 2.1±1.1 | ug/ml | PO, oral; low fat meal; | DRUGBANK |
| T Max | 6.5 | h | 5-8 | h | PO, oral; food; | DRUGBANK |
| Volume of Distribution | 288.5 | L | 256-321 | L | Apparent volume of distribution; | DRUGBANK |
| Half-life | 22.5 | h | 19-26 | h | Single dose; | DRUGBANK |
| Toxicity LD50 | 2001.0 | mg/kg | >2001 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 99.9 | % | >99.9 | % | Faeces excretion; Oral single dose; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 0.0100 | % | <0.01 | % | Urinary excretion; Oral single dose; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 20.8 | % | 20.8 | % | Faeces excretion; Oral single dose; normal,healthy; human, homo sapiens; Unchanged drug; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 400.0 | mg/day | 400 | mg/day | PO, oral | Venclexta | venetoclax | PDR |
| Max dose for adults | 400.0 | mg/day | 400 | mg/day | PO, oral | Venclexta | venetoclax | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | PO, oral | Venclexta | venetoclax | PDR |
| Max dose for geriatric | 400.0 | mg/day | 400 | mg/day | PO, oral | Venclexta | venetoclax | PDR |
| Max dose for geriatric | 400.0 | mg/day | 400 | mg/day | PO, oral | Venclexta | venetoclax | PDR |
| Max dose for geriatric | 600.0 | mg/day | 600 | mg/day | PO, oral | Venclexta | venetoclax | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1