Basic Information
| Drug ID | DDPD11431 |
|
| Drug Name | Moxidectin | |
| Molecular Weight | 639.83 | |
| Molecular Formula | C37H53NO8 | |
| CAS Number | 113507-06-5 | |
| SMILES | [H][C@@]12OC\C3=C/C=C/[C@H](C)C\C(C)=C\C[C@]4([H])C[C@@]([H])(C[C@]5(C\C(=N/OC)[C@H](C)[C@H](O5)C(\C)=C\C(C)C)O4)OC(=O)[C@]([H])(C=C(C)[C@H]1O)[C@@]23O | |
| External Links | ||
| DRUGBANK | DB11431 | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 6.0 | - | 6.0 | - | Menez C. et al. PLoS Negl Trop Dis. (2012) |
| Boiling Point | 160.0 | ℃ | 160 | ℃ | 'MSDS' |
| Melting Point | 149.5 | ℃ | 145-154 | ℃ | 'MSDS' |
| pKa | 12.8 | - | 12.8 | - | Brittain H. Profiles of Drug Substances, Excipients and Related Methodology. (2013) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 8726400.0 | ng.h/ml | 363.6 | mcg.day/ml | DRUGBANK | |
| C Max | 70.4 | ng/mg | 70.4 | mg/kg | DRUGBANK | |
| T Max | 8.9 | h | 0.37 | day | DRUGBANK | |
| Clearance | 3.5 | L/h | 3.5 | L/h | apparent clearance; | DRUGBANK |
| Volume of Distribution | 1.2 | L/kg | 1.2 | L/kg | DRUGBANK | |
| Half-life | 484.8 | h | 20.2 | day | terminal half-life; | DRUGBANK |
| Toxicity LD50 | 100.5 | mg/kg | 70-131 | mg/kg | mouse; | DRUGBANK |
| Eliminate Route | 2.0 | % | 2 | % | Faeces excretion; PO, oral; Unchanged drug; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1