Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD11363 ...
Drug Name Alectinib
Molecular Weight 482.6166
Molecular Formula C30H34N4O2
CAS Number 1256580-46-7
SMILES CCC1=CC2=C(C=C1N1CCC(CC1)N1CCOCC1)C(C)(C)C1=C(C3=CC=C(C=C3N1)C#N)C2=O
External Links
DRUGBANK DB11363
PubChem Compound 49806720
PDR 3844

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
pKa 7.05 - 7.05 - FDA Label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 37.0 % 37 % DRUGBANK
T Max 4.0 h 4 h DRUGBANK
Clearance 81.9 L/h 81.9 L/h apparent clearance; DRUGBANK
Clearance 217.0 L/h 217.0 L/h apparent clearance; DRUGBANK
Clearance 0.46 L/h/kg 7.69 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 4016.0 L 4016.0 L DRUGBANK
Volume of Distribution 6.4 L/kg 6.35 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 33.0 h 33 h elimination half-life; DRUGBANK
Half-life 31.0 h 31 h elimination half-life; DRUGBANK
Half-life 11.7 h 11.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 98.0 % 98 % Faeces excretion; DRUGBANK
Eliminate Route 0.50 % <0.5 % Urinary excretion; DRUGBANK
Eliminate Route 82.3 % 82.32 % Faeces excretion; Unchanged drug; DRUGBANK
Protein Binding 99.0 % >99 % plasma proteins; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 1200.0 mg/day 600 mg/dose PO, oral bid Alecensa alectinib PDR
Max dose for adults 600.0 mg/day 600 mg/day PO, oral bid Alecensa alectinib PDR
Max dose for geriatric 1200.0 mg/dose 600 mg/dose PO, oral bid Alecensa alectinib PDR
Max dose for geriatric 600.0 mg/day 600 mg/day PO, oral bid Alecensa alectinib PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1