Basic Information
| Drug ID | DDPD11362 |
|
| Drug Name | Selexipag | |
| Molecular Weight | 496.63 | |
| Molecular Formula | C26H32N4O4S | |
| CAS Number | 475086-01-2 | |
| SMILES | CC(C)N(CCCCOCC(=O)NS(C)(=O)=O)C1=NC(C2=CC=CC=C2)=C(N=C1)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB11362 | |
| PubChem Compound | 9913767 | |
| PDR | 3845 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 2.0 | h | 1-3 | h | PO, oral; | DRUGBANK | T Max | 3.5 | h | 3-4 | h | PO, oral; Active metabolite; | DRUGBANK |
| Clearance | 35.7 | L/h | 35.7±19.6 | L/h | Average clearance; | DRUGBANK |
| Half-life | 1.7 | h | 0.8-2.5 | h | terminal half-life; | DRUGBANK | Half-life | 9.9 | h | 6.2-13.5 | h | terminal half-life; Active metabolite; | DRUGBANK |
| Eliminate Route | 93.0 | % | 93 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 12.0 | % | 12 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 99.0 | % | ~99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 3.2 | mg/day | 3200 | mcg/day | PO, oral | Uptravi | selexipag | PDR |
| Max dose for geriatric | 3.2 | mg/day | 3200 | mcg/day | PO, oral | Uptravi | selexipag | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1