Basic Information
| Drug ID | DDPD09292 |
|
| Drug Name | Sacubitril | |
| Molecular Weight | 411.498 | |
| Molecular Formula | C24H29NO5 | |
| CAS Number | 149709-62-6 | |
| SMILES | CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C1=CC=CC=C1)NC(=O)CCC(O)=O | |
| External Links | ||
| DRUGBANK | DB09292 | |
| PubChem Compound | 9811834 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 60.0 | % | >60 | % | DRUGBANK | |
| T Max | 0.50 | h | 0.5 | h | DRUGBANK | T Max | 2.0 | h | 2 | h | Active metabolite; | DRUGBANK |
| Volume of Distribution | 103.0 | L | 103.0 | L | DRUGBANK | |
| Half-life | 2.4 | h | 1.1-3.6 | h | DRUGBANK | Half-life | 10.5 | h | 9.9-11.1 | h | Metabolite; | DRUGBANK |
| Eliminate Route | 60.0 | % | 52-68 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 42.5 | % | 37-48 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 95.5 | % | 94-97 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1