Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09274 ...
Drug Name Artesunate
Molecular Weight 384.425
Molecular Formula C19H28O8
CAS Number 88495-63-0
SMILES [H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@@]4(C)OO[C@@]13[C@]([H])(O[C@@H](OC(=O)CCC(O)=O)[C@@H]2C)O4
External Links
DRUGBANK DB09274
PubChem Compound 6917864

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 133.0 ℃ 131-135 ℃ MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 700.0 ng.h/ml 0.7 ug.h/ml DRUGBANK
AUC 3500.0 ng.h/ml 3.5 ug.h/ml Active metabolite; DRUGBANK
C Max 3300.0 ng/ml 3.3 ug/ml DRUGBANK
C Max 3100.0 ng/ml 3.1 ug/ml Active metabolite; DRUGBANK
T Max 0.13 h 0.5-15 min intravenous injection, IV; patients; adults; DRUGBANK
T Max 0.71 h 21-64 min intravenous injection, IV; patients; Children; DRUGBANK
T Max 0.17 h 8-12 min IM,intramuscular injection; DRUGBANK
Clearance 180.0 L/h 180.0 L/h DRUGBANK
Clearance 64.2 L/h/kg 1070 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 68.5 L 68.5 L DRUGBANK
Volume of Distribution 15.0 L/kg 15 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.30 h 0.3(0.1-1.8) h elimination half-life; DRUGBANK
Half-life 1.3 h 1.3(0.9-2.9) h elimination half-life; DRUGBANK
Half-life 0.80 h 48 min IM,intramuscular injection; DRUGBANK
Half-life 0.68 h 41 min IM,intramuscular injection; DRUGBANK
Half-life 0.22 h 0.22 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 56.1 % 56.1 % Urinary excretion; Rattus, Rat; DRUGBANK
Eliminate Route 38.5 % 38.5 % Faeces excretion; Rattus, Rat; DRUGBANK
Protein Binding 93.0 % ~93 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1