Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09241 ...
Drug Name Methylene blue
Molecular Weight 319.85
Molecular Formula C16H18ClN3S
CAS Number 61-73-4
SMILES [Cl-].CN(C)C1=CC2=[S+]C3=C(C=CC(=C3)N(C)C)N=C2C=C1
External Links
DRUGBANK DB09241
PubChem Compound 6099
PDR 24011

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 105.0 ℃ 100-110 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 180.0 L/h 3.0±0.7 L/min DRUGBANK
Volume of Distribution 0.70 mg/kg 10.0 mg/kg DRUGBANK
Half-life 5.8 h 5-6.5 h intravenous injection, IV; DRUGBANK
Toxicity LD50 1180.0 mg/kg 1180.0 mg/kg Rattus, Rat; DRUGBANK
Eliminate Route 75.0 % ~75 % Urinary excretion; PO, oral; DRUGBANK
Protein Binding 74.0 % 71-77 % plasma proteins; rabbit; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 2.0 mg/kg/day 2 mg/kg/day intravenous injection, IV Methylene Blue 1% methylene blue PDR
Max dose for infants 2.0 mg/kg/day 2 mg/kg/day intravenous injection, IV Methylene Blue 1% methylene blue PDR
Max dose for children 2.0 mg/kg/day 2 mg/kg/day intravenous injection, IV Methylene Blue 1% methylene blue PDR
Max dose for adolescents 2.0 mg/kg/day 2 mg/kg/day intravenous injection, IV Methylene Blue 1% methylene blue PDR
Max dose for adults 2.0 mg/kg/day 2 mg/kg/day intravenous injection, IV Methylene Blue 1% methylene blue PDR
Max dose for geriatric 2.0 mg/kg/day 2 mg/kg/day intravenous injection, IV Methylene Blue 1% methylene blue PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1