Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09237 ...
Drug Name Levamlodipine
Molecular Weight 408.88
Molecular Formula C20H25ClN2O5
CAS Number 103129-82-4
SMILES CCOC(=O)C1=C(COCCN)NC(C)=C([C@@H]1C1=CC=CC=C1Cl)C(=O)OC
External Links
DRUGBANK DB09237
PubChem Compound 9822750

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.3 - 3.3 - https://comptox.epa.gov/dashboard/dsstoxdb/results?formula=1&isotopes=1&search=C24H31ClN2O10
Boiling Point 413.0 ℃ 413 ℃ https://comptox.epa.gov/dashboard/dsstoxdb/results?formula=1&isotopes=1&search=C24H31ClN2O10
Melting Point 138.0 ℃ 138 ℃ https://comptox.epa.gov/dashboard/dsstoxdb/results?formula=1&isotopes=1&search=C24H31ClN2O10
Water Solubility 81000.0 mg/L 81 mg/ml http://www.selleckchem.com/products/levamlodipine.html
pKa 8.6 - 8.6 - FDA Label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 351.0 ng.h/ml 351±72 ng.h/ml PO, oral; Derivative; DRUGBANK
AUC 330.0 ng.h/ml 330±88 ng.h/ml PO, oral; Derivative; DRUGBANK
Bioavailability 77.0 % 64-90 % PO, oral; DRUGBANK
C Max 6.1 ng/ml 6.13±1.29 ng/ml PO, oral; Derivative; DRUGBANK
C Max 5.1 ng/ml 5.07±1.09 ng/ml PO, oral; Derivative; DRUGBANK
T Max 9.0 h 6-12 h PO, oral; DRUGBANK
T Max 8.4 h 8.4±3.6 h PO, oral; Derivative; DRUGBANK
T Max 10.7 h 10.7±3.4 h PO, oral; Derivative; DRUGBANK
Metabolic 90.0 % 90 % Liver metabolism; Inactive metabolite; DRUGBANK
Clearance 0.41 L/h/kg 6.9±1.6 ml/min/kg PO, oral; DRUGBANK
Clearance 0.44 L/h/kg 7.3±2.1 ml/min/kg PO, oral; DRUGBANK
Volume of Distribution 21.0 L/kg 21.0 L/kg DRUGBANK
Half-life 40.0 h 30-50 h DRUGBANK
Eliminate Route 60.0 % 60 % Urinary excretion; DRUGBANK
Protein Binding 93.0 % 93 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1