Basic Information

Drug ID DDPD09236 ...
Drug Name Lacidipine
Molecular Weight 455.551
Molecular Formula C26H33NO6
CAS Number 103890-78-4
SMILES CCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1\C=C\C(=O)OC(C)(C)C)C(=O)OCC
External Links
DRUGBANK DB09236
PubChem Compound 5311217

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 10.0 % <10 % DRUGBANK
C Max 3.7 ng/ml 1.6-5.7 ug/L Oral single dose; normal,healthy; adults; DRUGBANK
T Max 1.5 h 0.5-2.5 h PO, oral; DRUGBANK
Half-life 16.0 h 13-19 h terminal half-life; at steady state; DRUGBANK
Toxicity LD50 300.0 mg/kg 300.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 3200.0 mg/kg 3200.0 mg/kg PO, oral; rabbit; DRUGBANK
Toxicity LD50 980.0 mg/kg 980.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 70.0 % ~70 % Faeces excretion; DRUGBANK
Eliminate Route 30.0 % ~30 % Urinary excretion; DRUGBANK
Protein Binding 95.0 % >95 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1