Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 92.5 | ℃ | 92-93 | ℃ | MSDS |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 75.0 | % | 75 | % | PO, oral; | DRUGBANK |
| C Max | 300.0 | ng/ml | 300 | ng/ml | PO, oral; | DRUGBANK |
| T Max | 0.75 | h | 0.5-1 | h | PO, oral; | DRUGBANK |
| Tss | 108.0 | h | 96-120 | h | DRUGBANK | Tss | 108.0 | h | 96-120 | h | DRUGBANK |
| Clearance | 69.0 | L/h | 1.15 | L/min | Total clearance; | DRUGBANK | Clearance | 0.53 | L/h/kg | 8.9 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.2 | L/kg | ~1-1.4 | L/kg | Apparent volume of distribution; PO, oral; | DRUGBANK | Volume of Distribution | 1.4 | L/kg | 1.4 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.0 | h | ~1 | h | elimination half-life; | DRUGBANK | Half-life | 3.6 | h | 3.6 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 626.0 | mg/kg | 626.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 1220.0 | mg/kg | 1220.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 62.5 | mg/kg | 62.5 | mg/kg | PO, oral; dog; | DRUGBANK |
| Eliminate Route | 60.0 | % | >60 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 1.0 | % | ~1 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 25.0 | % | ~25 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1