DETAILS

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	5.17	-	5.17	-	US-EPA
Melting Point	207.0	℃	207	℃	Deriv of anthranilic acid, related structurally to mefenamic and flufenamic acids. (1966)
Water Solubility	1000.0	mg/L	1	mg/ml	'MSDS'
pKa	5.11	-	5.11	-	Mefenamic acid: analytical profile. (2005)

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
AUC	31500.0	ng.h/ml	13-50	mcg.h/ml		increasing doses ↑ ;	DRUGBANK
Bioavailability	75.0	%	75	%			DRUGBANK
C Max	11100.0	ng/ml	11.1	mcg/ml	PO, oral;		DRUGBANK
T Max	1.5	h	0.94-2.04	h			DRUGBANK
Metabolic	20.0	%	20	%	Liver metabolism; Urinary excretion;		DRUGBANK
Clearance	0.16	L/h/kg	0.142-0.175	L/h/kg			DRUGBANK
Clearance	4.3	L/h/kg	72.4	ml/min/kg	intravenous injection, IV;		DRUGBANK
Clearance	0.14	L/h/kg	2.37	ml/min/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	2.5	L/kg	1.79-3.2	L/kg	intravenous injection, IV;		DRUGBANK
Volume of Distribution	0.33	L/kg	0.33	L/kg	Steady state volume of distribution;		DRUGBANK
Volume of Distribution	0.16	L/kg	0.16	L/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Half-life	10.8	h	8.01-13.50	h			DRUGBANK
Half-life	6.1	h	6.1	h	intravenous injection, IV;		DRUGBANK
Half-life	2.2	h	2.15	h	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Toxicity LD50	600.0	mg/kg	200-1000	mg/kg			DRUGBANK
Eliminate Route	8.8	%	<8.8	%	Urinary excretion; Unchanged drug;		DRUGBANK
Protein Binding	99.7	%	99.7	%			DRUGBANK

Not Available

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1