Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09167 ...
Drug Name Dosulepin
Molecular Weight 295.44
Molecular Formula C19H21NS
CAS Number 113-53-1
SMILES CN(C)CC\C=C1/C2=CC=CC=C2CSC2=CC=CC=C12
External Links
DRUGBANK DB09167
PubChem Compound 5284550

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Boiling Point 340.7 ℃ 339.8-341.6 ℃ MSDS
Melting Point 132.8 ℃ 131-134.6 ℃ MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
C Max 37.6 ng/ml 37.6 ng/ml PO, oral; DRUGBANK
T Max 2.2 h 2.18 h PO, oral; DRUGBANK
Clearance 1.4 L/h/kg 1.36 l/h/kg Oral single dose; DRUGBANK
Volume of Distribution 45.0 L/kg 45.0 L/kg Apparent volume of distribution; PO, oral; DRUGBANK
Half-life 20.4 h ~20.4 h elimination half-life; PO, oral; DRUGBANK
Toxicity LD50 31.0 mg/kg 31.0 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity TDLo 90.0 mg/kg 90.0 mg/kg PO, oral; Infants; DRUGBANK
Toxicity TDLo 4.5 mg/kg 4.5 mg/kg PO, oral; adults;  Female, women; DRUGBANK
Eliminate Route 55.0 % 50-60 % Urinary excretion; DRUGBANK
Eliminate Route 27.5 % 15-40 % Faeces excretion; Bile excretion; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1