Basic Information
| Drug ID | DDPD09143 |
|
| Drug Name | Sonidegib | |
| Molecular Weight | 485.507 | |
| Molecular Formula | C26H26F3N3O3 | |
| CAS Number | 956697-53-3 | |
| SMILES | [H][C@]1(C)CN(C[C@@]([H])(C)O1)C1=CC=C(NC(=O)C2=CC=CC(=C2C)C2=CC=C(OC(F)(F)F)C=C2)C=N1 | |
| External Links | ||
| DRUGBANK | DB09143 | |
| PubChem Compound | 24775005 | |
| PDR | 3766 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 6.5 | % | 6-7 | % | PO, oral; fasting; | DRUGBANK | |
| T Max | 3.0 | h | 2-4 | h | PO, oral; fasting; | DRUGBANK | |
| Volume of Distribution | 9166.0 | L | 9166.0 | L | DRUGBANK | ||
| Half-life | 672.0 | h | ~28 | day | DRUGBANK | ||
| Eliminate Route | 70.0 | % | ~70 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 30.0 | % | ~30 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 97.0 | % | >97 | % | plasma proteins; | Plasma Concentration → ; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 200.0 | mg/day | 200 | mg/day | PO, oral | Odomzo | sonidegib | PDR |
| Max dose for geriatric | 200.0 | mg/day | 200 | mg/day | PO, oral | Odomzo | sonidegib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1