DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD09132
Drug Name	Gadoteric acid
Molecular Weight	558.65
Molecular Formula	C16H25GdN4O8
CAS Number	72573-82-1
SMILES	[Gd+3].OC(=O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1
External Links
	DRUGBANK	DB09132
	PubChem Compound	158536
	PDR	3146
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Metabolic	0	%	0	%		DRUGBANK
Clearance	0.0762	L/h/kg	1.27	ml/min/kg	Renal clearance; normal,healthy; Female, women;	DRUGBANK
Clearance	0.10	L/h/kg	1.74	ml/min/kg	Total clearance; normal,healthy; Female, women;	DRUGBANK
Clearance	0.0840	L/h/kg	1.4	ml/min/kg	Renal clearance; normal,healthy; Male, men;	DRUGBANK
Clearance	0.0984	L/h/kg	1.64	ml/min/kg	Total clearance; normal,healthy; Male, men;	DRUGBANK
Volume of Distribution	0.18	L/kg	179.0	ml/kg	at steady state; normal,healthy; Female, women;	DRUGBANK
Volume of Distribution	0.21	L/kg	211.0	ml/kg	at steady state; normal,healthy; Male, men;	DRUGBANK
Half-life	1.4	h	1.4	h	elimination half-life; Female, women;	DRUGBANK
Half-life	2.0	h	2.0	h	elimination half-life; Male, men;	DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for neonates	0.2	ml/kg/dose	0.2	ml/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for neonates	0.1	mmol/kg/dose	0.1	mmol/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for infants	0.2	ml/kg/dose	0.2	ml/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for infants	0.1	mmoL/kg/dose	0.1	mmoL/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for children	0.2	ml/kg/dose	0.2	ml/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for children	0.1	mmol/kg/dose	0.1	mmol/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for adolescents	0.2	ml/kg/dose	0.2	mL/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for adolescents	0.1	mmol/kg/dose	0.1	mmol/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for adults	0.2	ml/kg/dose	0.2	ml/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for adults	0.1	mmoL/kg/dose	0.1	mmoL/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for geriatric	0.2	ml/kg/dose	0.2	ml/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR
Max dose for geriatric	0.1	mmol/kg/dose	0.1	mmol/kg/dose	intravenous injection, IV	Dotarem Injection	gadoterate meglumine	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1