Basic Information

Drug ID DDPD09128 ...
Drug Name Brexpiprazole
Molecular Weight 433.57
Molecular Formula C25H27N3O2S
CAS Number 913611-97-9
SMILES O=C1NC2=CC(OCCCCN3CCN(CC3)C3=C4C=CSC4=CC=C3)=CC=C2C=C1
External Links
DRUGBANK DB09128
PubChem Compound 11978813
PDR 3759
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 95.0 % 95 % PO, oral; food; food → ; DRUGBANK
T Max 4.0 h 4 h DRUGBANK
Tss 264.0 h 10-12 day DRUGBANK
Clearance 0.0198 L/h/kg 19.8 ml/h/kg DRUGBANK
Clearance 0.0204 L/h/kg 0.34 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.6 L/kg 1.56 L/kg intravenous injection, IV; DRUGBANK
Volume of Distribution 1.5 L/kg 1.46 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 91.0 h 91 h DRUGBANK
Half-life 96.0 h 96 h Metabolite; DRUGBANK
Half-life 54.4 h 54.37 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 25.0 % ~25 % Urinary excretion; DRUGBANK
Eliminate Route 46.0 % ~46 % Faeces excretion; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 14.0 % ~14 % Faeces excretion; Unchanged drug; DRUGBANK
Protein Binding 99.0 % >99 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 4.0 mg/day 4 mg/day PO, oral Rexulti brexpiprazole PDR
Max dose for geriatric 4.0 mg/day 4 mg/day PO, oral Rexulti brexpiprazole PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1