Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 214.0 | ℃ | 210-218 | ℃ | Bayer Product Monograph |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 91.0 | % | 91 | % | PO, oral; | DRUGBANK |
| C Max | 47.0 | ng/ml | 47 | ng/ml | Oral single dose; | DRUGBANK |
| T Max | 1.5 | h | 1.5 | h | Oral single dose; | DRUGBANK |
| Tss | 48.0 | h | 2 | day | PO, oral; | DRUGBANK |
| Clearance | 3.8 | L/h | 64.0 | ml/min | Total clearance; | DRUGBANK | Clearance | 0.0774 | L/h/kg | 1.29 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 40.0 | L | 40.0 | L | Apparent volume of distribution; | DRUGBANK | Volume of Distribution | 0.60 | L/kg | 0.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 9.5 | h | ~9-10 | h | elimination half-life; | DRUGBANK | Half-life | 14.0 | h | 14 | h | Urinary excretion; | DRUGBANK | Half-life | 11.0 | h | 11 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 4.0 | mg/kg | 4.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Protein Binding | 90.0 | % | 90 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1