Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09095 ...
Drug Name Difluocortolone
Molecular Weight 394.459
Molecular Formula C22H28F2O4
CAS Number 2607-06-9
SMILES [H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
External Links
DRUGBANK DB09095
PubChem Compound 11954369

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.86 - 3.86 - Lamparczyk H. CRC Handbook of Chromatography. (1992)
Boiling Point 534.0 ℃ 534 ℃ 'MSDS'
Melting Point 220.0 ℃ 220 ℃ 'MSDS'
Water Solubility 2.03 mg/L 2.03 mg/L Lamparczyk H. CRC Handbook of Chromatography. 1992)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 10.8 ng.h/ml 10.8 ng.h/ml Rectal Administration; DRUGBANK
C Max 0.75 ng/ml 0.75 ng/ml Rectal Administration; DRUGBANK
T Max 4.8 h 4.75±2.09 h Rectal Administration; DRUGBANK
Half-life 4.5 h ~4-5 h DRUGBANK
Half-life 9.0 h ~9 h DRUGBANK
Eliminate Route 75.0 % 75 % Urinary excretion; DRUGBANK
Eliminate Route 25.0 % 25 % Faeces excretion; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1