Basic Information
| Drug ID | DDPD09083 |
|
| Drug Name | Ivabradine | |
| Molecular Weight | 468.594 | |
| Molecular Formula | C27H36N2O5 | |
| CAS Number | 155974-00-8 | |
| SMILES | COC1=C(OC)C=C2[C@@H](CN(C)CCCN3CCC4=CC(OC)=C(OC)C=C4CC3=O)CC2=C1 | |
| External Links | ||
| DRUGBANK | DB09083 | |
| PubChem Compound | 132999 | |
| PDR | 3713 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 40.0 | % | ~40 | % | PO, oral; | DRUGBANK |
| Clearance | 24.0 | L/h | 400.0 | ml/min | Total clearance; | DRUGBANK | Clearance | 4.2 | L/h | 70.0 | ml/min | Renal clearance; | DRUGBANK | Clearance | 0.62 | L/h/kg | 10.27 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 100.0 | L | 100.0 | L | DRUGBANK | Volume of Distribution | 1.7 | L/kg | 1.66 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 2.0 | h | 2 | h | DRUGBANK | |
| Protein Binding | 70.0 | % | 70 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 0.4 | mg/kg/day | 0.2 | mg/kg/dose | PO, oral | bid | Corlanor | ivabradine | PDR |
| Max dose for children | 7.5 | mg | 7.5 | mg | PO, oral | bid | Corlanor | ivabradine | PDR |
| Max dose for children | 0.6 | mg/kg/day | 0.3 | mg/kg/dose | PO, oral | bid | Corlanor | ivabradine | PDR |
| Max dose for children | 7.5 | mg/dose | 7.5 | mg/dose | PO, oral | Corlanor | ivabradine | PDR | |
| Max dose for adolescents | 7.5 | mg | 7.5 | mg | PO, oral | bid | Corlanor | ivabradine | PDR |
| Max dose for adolescents | 0.3 | mg/kg/dose | 0.3 | mg/kg/dose | PO, oral | bid | Corlanor | ivabradine | PDR |
| Max dose for adolescents | 7.5 | mg/dose | 7.5 | mg/dose | PO, oral | Corlanor | ivabradine | PDR | |
| Max dose for adults | 7.5 | mg | 7.5 | mg | PO, oral | bid | Corlanor | ivabradine | PDR |
| Max dose for geriatric | 7.5 | mg | 7.5 | mg | PO, oral | bid | Corlanor | ivabradine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1