Basic Information
| Drug ID | DDPD09078 |
|
| Drug Name | Lenvatinib | |
| Molecular Weight | 426.86 | |
| Molecular Formula | C21H19ClN4O4 | |
| CAS Number | 417716-92-8 | |
| SMILES | COC1=C(C=C2C(OC3=CC=C(NC(=O)NC4CC4)C(Cl)=C3)=CC=NC2=C1)C(N)=O | |
| External Links | ||
| DRUGBANK | DB09078 | |
| PubChem Compound | 9823820 | |
| PDR | 3687 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.3 | - | 3.3 | - | FDA Label |
| pKa | 5.05 | - | 5.05 | - | FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 2.5 | h | 1-4 | h | DRUGBANK | |
| Half-life | 28.0 | h | ~28 | h | elimination half-life; | DRUGBANK |
| Eliminate Route | 64.0 | % | ~64 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 25.0 | % | ~25 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 98.5 | % | 98-99 | % | plasma proteins; high protein binding; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 24.0 | mg/day | 24 | mg/day | PO, oral | Lenvima | lenvatinib | PDR |
| Max dose for adults | 18.0 | mg/day | 18 | mg/day | PO, oral | Lenvima | lenvatinib | PDR |
| Max dose for adults | 12.0 | mg/day | 12 | mg/day | PO, oral | Lenvima | lenvatinib | PDR |
| Max dose for geriatric | 24.0 | mg/day | 24 | mg/day | PO, oral | Lenvima | lenvatinib | PDR |
| Max dose for geriatric | 18.0 | mg/day | 18 | mg/day | PO, oral | Lenvima | lenvatinib | PDR |
| Max dose for geriatric | 12.0 | mg/day | 12 | mg/day | PO, oral | Lenvima | lenvatinib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1