Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09075 ...
Drug Name Edoxaban
Molecular Weight 548.06
Molecular Formula C24H30ClN7O4S
CAS Number 480449-70-5
SMILES CN(C)C(=O)[C@H]1CC[C@H](NC(=O)C(=O)NC2=NC=C(Cl)C=C2)[C@@H](C1)NC(=O)C1=NC2=C(CN(C)CC2)S1
External Links
DRUGBANK DB09075
PubChem Compound 10280735
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
pKa 6.7 - 6.7 - FDA Label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 62.0 % 62 % PO, oral; DRUGBANK
T Max 1.5 h 1-2 h PO, oral; DRUGBANK
Clearance 22.0 L/h 22.0 L/h DRUGBANK
Clearance 0.31 L/h/kg 5.19 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 107.0 L 107.0 L Steady state volume of distribution; DRUGBANK
Volume of Distribution 1.5 L/kg 1.53 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 12.0 h 10-14 h elimination half-life; PO, oral; DRUGBANK
Half-life 6.7 h 6.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 55.0 % ~55 % plasma proteins; high protein binding; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1