Basic Information
| Drug ID | DDPD09074 |
|
| Drug Name | Olaparib | |
| Molecular Weight | 434.4628 | |
| Molecular Formula | C24H23FN4O3 | |
| CAS Number | 763113-22-0 | |
| SMILES | FC1=CC=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1C(=O)N1CCN(CC1)C(=O)C1CC1 | |
| External Links | ||
| DRUGBANK | DB09074 | |
| PDR | 3655 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 25.8 | ng.h/ml | 25.8 | mcg.h/L | PO, oral; | DRUGBANK |
| C Max | 6900.0 | ng/ml | 4.7-9.1 | mcg/ml | PO, oral; | DRUGBANK |
| T Max | 2.0 | h | 1-3 | h | PO, oral; | DRUGBANK |
| Clearance | 8.4 | L/h | 4.6-12.1 | L/h | Total clearance; | DRUGBANK |
| Volume of Distribution | 40.3 | L | 40.3 | L | DRUGBANK | |
| Half-life | 8.0 | h | 5-11 | h | elimination half-life; | DRUGBANK |
| Eliminate Route | 44.0 | % | 44 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 42.0 | % | 42 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 82.0 | % | 82 | % | plasma proteins; high protein binding; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | bid | Lynparza | olaparib | PDR |
| Max dose for geriatric | 300.0 | mg/day | 300 | mg/day | PO, oral | bid | Lynparza | olaparib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1