Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09072 ...
Drug Name Sodium oxybate
Molecular Weight 126.087
Molecular Formula C4H7NaO3
CAS Number 502-85-2
SMILES [Na+].OCCCC([O-])=O
External Links
DRUGBANK DB09072
PubChem Compound 23663870
PDR 281

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 145.5 ℃ 145-146 ℃ MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 88.0 % 88 % DRUGBANK
T Max 0.69 h 30.7-51.9 min DRUGBANK
Clearance 67.7 L/h 895-1361 ml/min Total clearance; DRUGBANK
Volume of Distribution 52.7 L 37.7-67.7 L DRUGBANK
Half-life 0.75 h 0.5-1 h DRUGBANK
Toxicity LD50 9690.0 mg/kg 9690.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 5.0 % <5 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 1.0 % <1 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 9000.0 mg/day 9 g/day PO, oral Xyrem sodium oxybate PDR
Max dose for children 7500.0 mg/day 7.5 g/day PO, oral Xyrem sodium oxybate PDR
Max dose for children 6000.0 mg/day 6 g/day PO, oral Xyrem sodium oxybate PDR
Max dose for children 6000.0 mg/day 6 g/day PO, oral Xyrem sodium oxybate PDR
Max dose for adolescents 9000.0 mg/day 9 g/day PO, oral Xyrem sodium oxybate PDR
Max dose for adolescents 7500.0 mg/day 7.5 g/day PO, oral Xyrem sodium oxybate PDR
Max dose for adolescents 6000.0 mg/day 6 g/day PO, oral Xyrem sodium oxybate PDR
Max dose for adults 9.0 g/night 9 g/night PO, oral Xyrem sodium oxybate PDR
Max dose for geriatric 9.0 g/night 9 g/night PO, oral Xyrem sodium oxybate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1