Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09069 ...
Drug Name Trimetazidine
Molecular Weight 266.341
Molecular Formula C14H22N2O3
CAS Number 5011-34-7
SMILES COC1=C(OC)C(OC)=C(CN2CCNCC2)C=C1
External Links
DRUGBANK DB09069
PubChem Compound 21109
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.04 - 1.04 - Reymond F, Steyaert G, Carrupt PA, Morin D, Tillement JP, Girault HH, Testa B. (1999). The pH-partition profile of the anti-ischemic drug trimetazidine may explain its reduction of intracellular acidosis. Pharm Res; 16(5):616-24.
pKa 4.45 - 4.45±0.02,9.14±0.02 - DRUGBANK
pKa 9.14 - 4.45±0.02,9.14±0.02 - Reymond F, Steyaert G, Carrupt PA, Morin D, Tillement JP, Girault HH, Testa B. (1999). The pH-partition profile of the anti-ischemic drug trimetazidine may explain its reduction of intracellular acidosis. Pharm Res; 16(5):616-24.

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 75.0 % 75 % DRUGBANK
Half-life 8.0 h ~8 h extended release formulation; young; DRUGBANK
Half-life 12.0 h ~12 h extended release formulation; Elderly; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1