Basic Information
| Drug ID | DDPD09063 |
|
| Drug Name | Ceritinib | |
| Molecular Weight | 558.14 | |
| Molecular Formula | C28H36ClN5O3S | |
| CAS Number | 1032900-25-6 | |
| SMILES | CC(C)OC1=C(NC2=NC(NC3=CC=CC=C3S(=O)(=O)C(C)C)=C(Cl)C=N2)C=C(C)C(=C1)C1CCNCC1 | |
| External Links | ||
| DRUGBANK | DB09063 | |
| PubChem Compound | 57379345 | |
| PDR | 3498 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| pKa | 6.9 | - | 4.1,9.7 | - | FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| T Max | 5.0 | h | 4-6 | h | PO, oral; | DRUGBANK | |
| Clearance | 33.2 | L/h | 33.2 | L/h | apparent clearance; | DRUGBANK | Clearance | 88.5 | L/h | 88.5 | L/h | apparent clearance; Single dose; | DRUGBANK |
| Volume of Distribution | 4230.0 | L | 4230.0 | L | Apparent volume of distribution; Single dose; | DRUGBANK | |
| Half-life | 41.0 | h | 41 | h | terminal half-life; | DRUGBANK | |
| Eliminate Route | 92.3 | % | 92.3 | % | Faeces excretion; Oral single dose; | DRUGBANK | Eliminate Route | 1.3 | % | 1.3 | % | Urinary excretion; Oral single dose; | DRUGBANK | Eliminate Route | 62.8 | % | ~62.8 | % | Faeces excretion; Oral single dose; Unchanged drug; | DRUGBANK |
| Protein Binding | 97.0 | % | 97 | % | plasma proteins; human, homo sapiens; | Plasma Concentration → ; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 450.0 | mg/day | 450 | mg/day | PO, oral | Zykadia | ceritinib | PDR |
| Max dose for geriatric | 450.0 | mg/day | 450 | mg/day | PO, oral | Zykadia | ceritinib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1