Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09050 ...
Drug Name Ceftolozane
Molecular Weight 666.69
Molecular Formula C23H30N12O8S2
CAS Number 689293-68-3
SMILES CN1C(N)=C(NC(=O)NCCN)C=[N+]1CC1=C(N2[C@H](SC1)[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=NSC(N)=N1)C2=O)C([O-])=O
External Links
DRUGBANK DB09050
PubChem Compound 53234134

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -6.17 - -6.17 - https://www.chemsrc.com/en/cas/689293-68-3_1197589.html

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 172000.0 ng.h/ml 172.0 mcg.h/ml intravenous injection, IV; DRUGBANK
C Max 69100.0 ng/ml 69.1 mcg/ml intravenous injection, IV; DRUGBANK
Metabolic 0 % 0 % DRUGBANK
Clearance 5.1 L/h 3.41 – 6.69 L/h Renal clearance; Single dose; DRUGBANK
Clearance 0.0696 L/h/kg 1.16 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 13.5 L 13.5 L DRUGBANK
Volume of Distribution 0.17 L/kg 0.17 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.8 h 2.77 h DRUGBANK
Half-life 3.1 h 3.12 h Multiple dose; DRUGBANK
Half-life 2.6 h 2.58 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 18.5 % 16-21 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1