Basic Information
| Drug ID | DDPD09049 |
|
| Drug Name | Naloxegol | |
| Molecular Weight | 651.794 | |
| Molecular Formula | C34H53NO11 | |
| CAS Number | 854601-70-0 | |
| SMILES | COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@@]2(O)[C@H]3CC4=CC=C(O)C5=C4[C@@]2(CCN3CC=C)[C@H]1O5 | |
| External Links | ||
| DRUGBANK | DB09049 | |
| PubChem Compound | 56959087 | |
| PDR | 3693 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 2.0 | h | <2 | h | PO, oral; | DRUGBANK |
| Volume of Distribution | 1554.0 | L | 968-2140 | L | DRUGBANK | |
| Half-life | 8.5 | h | 6-11 | h | DRUGBANK | |
| Eliminate Route | 68.0 | % | 68 | % | Faeces excretion; PO, oral; | DRUGBANK | Eliminate Route | 16.0 | % | 16 | % | Urinary excretion; PO, oral; | DRUGBANK |
| Protein Binding | 4.2 | % | ~4.2 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 25.0 | mg/day | 25 | mg/day | PO, oral | qd | Movantik | naloxegol | PDR |
| Max dose for geriatric | 25.0 | mg/day | 25 | mg/day | PO, oral | qd | Movantik | naloxegol | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1