Basic Information

Drug ID DDPD09048 ...
Drug Name Netupitant
Molecular Weight 578.603
Molecular Formula C30H32F6N4O
CAS Number 290297-26-6
SMILES CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=CC=CC=C1C)N1CCN(C)CC1
External Links
DRUGBANK DB09048
PubChem Compound 6451149

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
T Max 5.0 h 5 h Oral single dose; DRUGBANK
Clearance 20.3 L/h 20.3±9.2 L/h Total clearance; DRUGBANK
Clearance 0.17 L/h/kg 2.83 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1982.0 L 1982±906 L Average volume of distribution; tumor; patients; DRUGBANK
Volume of Distribution 5.5 L/kg 5.54 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 96.0 h 96 h DRUGBANK
Half-life 34.3 h 34.28 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 99.5 % >99.5 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1