Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09039 ...
Drug Name Eliglustat
Molecular Weight 404.551
Molecular Formula C23H36N2O4
CAS Number 491833-29-5
SMILES CCCCCCCC(=O)N[C@H](CN1CCCC1)[C@H](O)C1=CC=C2OCCOC2=C1
External Links
DRUGBANK DB09039
PubChem Compound 23652731
PDR 3601

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
T Max 1.8 h 1.5-2 h Oral multiple dose; CYP2D6 genetic polymorphisms; extensive metabolizers, EM; DRUGBANK
Clearance 88.0 L/h 88.0 L/h CYP2D6 genetic polymorphisms; DRUGBANK
Clearance 1.3 L/h/kg 20.95 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 835.0 L 835.0 L CYP2D6 genetic polymorphisms; DRUGBANK
Half-life 6.5 h 6.5 h extensive metabolizers, EM; DRUGBANK
Half-life 8.9 h 8.9 h poor metabolizers, PM; DRUGBANK
Half-life 7.7 h 7.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 41.8 % 41.8 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 51.4 % 51.4 % Faeces excretion; PO, oral; DRUGBANK
Protein Binding 79.5 % 76-83 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adolescents 84.0 mg/dose 84 mg/dose PO, oral bid Cerdelga eliglustat PDR
Max dose for adolescents 84.0 mg/dose 84 mg/dose PO, oral bid Cerdelga eliglustat PDR
Max dose for adolescents 84.0 mg/dose/day 84 mg/dose/day PO, oral qd Cerdelga eliglustat PDR
Max dose for geriatric 168.0 mg/dose 84 mg/dose PO, oral bid Cerdelga eliglustat PDR
Max dose for geriatric 168.0 mg/dose 84 mg/dose PO, oral bid Cerdelga eliglustat PDR
Max dose for geriatric 84.0 mg/dose/day 84 mg/dose/day PO, oral qd Cerdelga eliglustat PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1