Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD09038 ...
Drug Name Empagliflozin
Molecular Weight 450.91
Molecular Formula C23H27ClO7
CAS Number 864070-44-0
SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1=CC=C(Cl)C(CC2=CC=C(O[C@H]3CCOC3)C=C2)=C1
External Links
DRUGBANK DB09038
PubChem Compound 11949646
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Water Solubility 280.0 mg/L 0.28 mg/ml Canadian monograph

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 843.2 ng.h/ml 1870.0 nmol.h/L PO, oral; DRUGBANK
AUC 2137.3 ng.h/ml 4740.0 nmol.h/L PO, oral; DRUGBANK
C Max 116.8 ng/ml 259 nmol/L PO, oral; DRUGBANK
C Max 309.8 ng/ml 687 nmol/L PO, oral; DRUGBANK
T Max 1.5 h 1.5 h PO, oral; DRUGBANK
Clearance 10.6 L/h 10.6 L/h apparent clearance; PO, oral; DRUGBANK
Volume of Distribution 73.8 L 73.8 L Steady state volume of distribution; DRUGBANK
Half-life 12.4 h 12.4 h elimination half-life; DRUGBANK
Eliminate Route 41.2 % ~41.2 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 54.4 % ~54.4 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 27.2 % ~27.2 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Protein Binding 86.2 % ~86.2 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1