Basic Information
| Drug ID | DDPD09027 |
|
| Drug Name | Ledipasvir | |
| Molecular Weight | 888.9999 | |
| Molecular Formula | C49H54F2N8O6 | |
| CAS Number | 1256388-51-8 | |
| SMILES | COC(=O)N[C@@H](C(C)C)C(=O)N1CC2(CC2)C[C@H]1C1=NC(=CN1)C1=CC=C2C3=CC=C(C=C3C(F)(F)C2=C1)C1=CC=C2NC(=NC2=C1)[C@@H]1[C@H]2CC[C@H](C2)N1C(=O)[C@@H](NC(=O)OC)C(C)C | |
| External Links | ||
| DRUGBANK | DB09027 | |
| PubChem Compound | 67505836 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.8 | - | 3.8 | - | FDA Label |
| pKa | 4.0 | - | 4.0,5.0 | - | DRUGBANK | pKa | 5.0 | - | 4.0,5.0 | - | FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 323.0 | ng/ml | 323 | ng/ml | PO, oral; | DRUGBANK |
| T Max | 4.3 | h | 4-4.5 | h | PO, oral; | DRUGBANK |
| Half-life | 47.0 | h | 47 | h | DRUGBANK | |
| Eliminate Route | 86.0 | % | ~86 | % | Faeces excretion; Oral single dose; | DRUGBANK | Eliminate Route | 1.0 | % | ~1 | % | Urinary excretion; Oral single dose; | DRUGBANK |
| Protein Binding | 99.8 | % | >99.8 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1