Basic Information
| Drug ID | DDPD08934 |
|
| Drug Name | Sofosbuvir | |
| Molecular Weight | 529.458 | |
| Molecular Formula | C22H29FN3O9P | |
| CAS Number | 1190307-88-0 | |
| SMILES | CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(F)[C@@H]1O)OC1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB08934 | |
| PubChem Compound | 45375808 | |
| PDR | 3413 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.62 | - | 1.62 | - | FDA Label |
| pKa | 9.3 | - | 9.3 | - | FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 567.0 | ng/ml | 567 | ng/ml | PO, oral; | DRUGBANK |
| T Max | 1.3 | h | 0.5-2 | h | PO, oral; | DRUGBANK |
| Half-life | 0.40 | h | 0.4 | h | terminal half-life; | DRUGBANK |
| Eliminate Route | 80.0 | % | 80 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 14.0 | % | 14 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 2.5 | % | 2.5 | % | lung excretion; | DRUGBANK |
| Protein Binding | 63.0 | % | ~61-65 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 400.0 | mg/day | 400 | mg/day | PO, oral | Sovaldi | sofosbuvir | PDR |
| Max dose for children | 200.0 | mg/day | 200 | mg/day | PO, oral | Sovaldi | sofosbuvir | PDR |
| Max dose for children | 150.0 | mg/day | 150 | mg/day | PO, oral | Sovaldi | sofosbuvir | PDR |
| Max dose for adolescents | 400.0 | mg/day | 400 | mg/day | PO, oral | Sovaldi | sofosbuvir | PDR |
| Max dose for adolescents | 200.0 | mg/day | 200 | mg/day | PO, oral | Sovaldi | sofosbuvir | PDR |
| Max dose for adults | 400.0 | mg/day | 400 | mg/day | PO, oral | Sovaldi | sofosbuvir | PDR |
| Max dose for geriatric | 400.0 | mg/day | 400 | mg/day | PO, oral | Sovaldi | sofosbuvir | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1