Basic Information
| Drug ID | DDPD08932 |
|
| Drug Name | Macitentan | |
| Molecular Weight | 588.273 | |
| Molecular Formula | C19H20Br2N6O4S | |
| CAS Number | 441798-33-0 | |
| SMILES | CCCNS(=O)(=O)NC1=C(C(OCCOC2=NC=C(Br)C=N2)=NC=N1)C1=CC=C(Br)C=C1 | |
| External Links | ||
| DRUGBANK | DB08932 | |
| PubChem Compound | 16004692 | |
| PDR | 3376 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 8.0 | h | 8 | h | PO, oral; | DRUGBANK |
| Volume of Distribution | 50.0 | L | 50.0 | L | DRUGBANK | |
| Half-life | 16.0 | h | 16 | h | DRUGBANK | Half-life | 48.0 | h | 48 | h | Active metabolite; | DRUGBANK |
| Eliminate Route | 50.0 | % | 50 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 24.0 | % | 24 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 10.0 | mg/day | 10 | mg/day | PO, oral | Opsumit | macitentan | PDR |
| Max dose for geriatric | 10.0 | mg/day | 10 | mg/day | PO, oral | Opsumit | macitentan | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1