Basic Information
| Drug ID | DDPD08916 |
|
| Drug Name | Afatinib | |
| Molecular Weight | 485.938 | |
| Molecular Formula | C24H25ClFN5O3 | |
| CAS Number | 850140-72-6 | |
| SMILES | CN(C)C\C=C\C(=O)NC1=C(O[C@H]2CCOC2)C=C2N=CN=C(NC3=CC(Cl)=C(F)C=C3)C2=C1 | |
| External Links | ||
| DRUGBANK | DB08916 | |
| PubChem Compound | 10184653 | |
| PDR | 3274 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 3.5 | h | 2-5 | h | PO, oral; | DRUGBANK |
| Clearance | 91.8 | L/h | 1530.0 | ml/min | apparent clearance; normal,healthy; Male, men; | DRUGBANK |
| Volume of Distribution | 4500.0 | L | 4500.0 | L | normal,healthy; Male, men; | DRUGBANK |
| Half-life | 37.0 | h | 37 | h | effective half-life; | DRUGBANK | Half-life | 344.0 | h | 344 | h | terminal half-life; Multiple dose; patients; | DRUGBANK |
| Eliminate Route | 85.9 | % | 85.9 | % | Faeces excretion; PO, oral; human, homo sapiens; | DRUGBANK | Eliminate Route | 4.3 | % | 4.3 | % | Urinary excretion; PO, oral; human, homo sapiens; | DRUGBANK |
| Protein Binding | 95.0 | % | ~95 | % | plasma proteins; high protein binding; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral | Gilotrif | afatinib | PDR |
| Max dose for adults | 50.0 | mg/day | 50 | mg/day | PO, oral | Gilotrif | afatinib | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Gilotrif | afatinib | PDR |
| Max dose for geriatric | 50.0 | mg/day | 50 | mg/day | PO, oral | Gilotrif | afatinib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1