DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD08911
Drug Name	Trametinib
Molecular Weight	615.3948
Molecular Formula	C26H23FIN5O4
CAS Number	871700-17-3
SMILES	CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=CC=C(I)C=C1F)C1=CC(NC(C)=O)=CC=C1
External Links
	DRUGBANK	DB08911
	PubChem Compound	11707110
	PDR	3157
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Melting Point	298.0	℃	293-303	℃	MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Bioavailability	72.0	%	72	%	Oral single dose;	DRUGBANK
C Max	22.2	ng/ml	22.2	ng/ml	PO, oral;	DRUGBANK
T Max	1.5	h	1.5	h	PO, oral; BRAF V600 mutation-positive melanoma;	DRUGBANK
Clearance	4.9	L/h	4.9	L/h	apparent clearance;	DRUGBANK
Clearance	0.0480	L/h/kg	0.8	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	214.0	L	214.0	L	Apparent volume of distribution;	DRUGBANK
Volume of Distribution	13.9	L/kg	13.94	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	104.4	h	3.9-4.8	day	elimination half-life;	DRUGBANK
Half-life	229.0	h	229	h	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Eliminate Route	80.0	%	80	%	Faeces excretion;	DRUGBANK
Eliminate Route	0.10	%	<0.1	%	Urinary excretion;	DRUGBANK
Protein Binding	97.4	%	97.4	%	plasma proteins; human, homo sapiens;	DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	2.0	mg/day	2	mg/day	PO, oral	Mekinist	trametinib	PDR
Max dose for geriatric	2.0	mg/day	2	mg/day	PO, oral	Mekinist	trametinib	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1