Basic Information
| Drug ID | DDPD08909 |
|
| Drug Name | Glycerol phenylbutyrate | |
| Molecular Weight | 530.6512 | |
| Molecular Formula | C33H38O6 | |
| CAS Number | 611168-24-2 | |
| SMILES | O=C(CCCC1=CC=CC=C1)OCC(COC(=O)CCCC1=CC=CC=C1)OC(=O)CCCC1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB08909 | |
| PubChem Compound | 10482134 | |
| PDR | 3105 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 37000.0 | ng/ml | 37.0 | ug/ml | Oral single dose; fasting; Active metabolite; | DRUGBANK | C Max | 14900.0 | ng/ml | 14.9 | ug/ml | Oral single dose; fasting; Active metabolite; | DRUGBANK | C Max | 30200.0 | ng/ml | 30.2 | ug/ml | Oral single dose; fasting; Active metabolite; | DRUGBANK |
| T Max | 2.0 | h | 2 | h | Oral single dose; fasting; Active metabolite; | DRUGBANK | T Max | 4.0 | h | 4 | h | Oral single dose; fasting; Active metabolite; | DRUGBANK | T Max | 4.0 | h | 4 | h | Oral single dose; fasting; Active metabolite; | DRUGBANK | T Max | 8.0 | h | 8 | h | PO, oral; adults; Urea Cycle Disorder; | DRUGBANK | T Max | 10.0 | h | 10 | h | PO, oral; adults; Urea Cycle Disorder; | DRUGBANK | T Max | 12.0 | h | 12 | h | PO, oral; adults; Urea Cycle Disorder; | DRUGBANK |
| Eliminate Route | 68.9 | % | 68.9 | % | Urinary excretion; adults; human, homo sapiens; | DRUGBANK | Eliminate Route | 66.5 | % | 66.5 | % | Urinary excretion; Children; usual childhood diseases; human, homo sapiens; | DRUGBANK |
| Protein Binding | 36.0 | % | 27-45 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 17.5 | ml/day | 17.5 | ml/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for neonates | 19000.0 | mg/day | 19 | g/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for infants | 17.5 | ml/day | 17.5 | ml/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for infants | 19.0 | g/day | 19 | g/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for children | 17.5 | ml/day | 17.5 | ml/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for children | 19000.0 | mg/day | 19 | g/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for adolescents | 17.5 | ml/day | 17.5 | ml/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for adolescents | 19000.0 | mg/day | 19 | g/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for adults | 17.5 | ml/day | 17.5 | ml/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for adults | 19000.0 | mg/day | 19 | g/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for geriatric | 17.5 | ml/day | 17.5 | ml/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
| Max dose for geriatric | 19000.0 | mg/day | 19 | g/day | PO, oral | Ravicti | glycerol phenylbutyrate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1