Basic Information
| Drug ID | DDPD08897 |
|
| Drug Name | Aclidinium | |
| Molecular Weight | 484.651 | |
| Molecular Formula | C26H30NO4S2 | |
| CAS Number | 727649-81-2 | |
| SMILES | OC(C(=O)O[C@H]1C[N+]2(CCCOC3=CC=CC=C3)CCC1CC2)(C1=CC=CS1)C1=CC=CS1 | |
| External Links | ||
| DRUGBANK | DB08897 | |
| PubChem Compound | 11434515 | |
| PDR | 2561 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 6.0 | % | 6 | % | normal,healthy; | DRUGBANK |
| T Max | 0.17 | h | 10 | min | normal,healthy; | DRUGBANK |
| Tss | 48.0 | h | 2 | day | normal,healthy; | DRUGBANK |
| Clearance | 170.0 | L/h | 170.0 | L/h | Total clearance; intravenous injection, IV; normal,healthy; young; | DRUGBANK |
| Volume of Distribution | 300.0 | L | 300.0 | L | intravenous injection, IV; | DRUGBANK |
| Half-life | 0.0400 | h | 2.4 | min | elimination half-life; | DRUGBANK | Half-life | 6.5 | h | 5-8 | h | effective half-life; | DRUGBANK |
| Eliminate Route | 59.5 | % | ~54-65 | % | Urinary excretion; intravenous injection, IV; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 26.5 | % | ~20-33 | % | Faeces excretion; intravenous injection, IV; normal,healthy; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 0.8 | mg/day | 800 | mcg/day | PO, oral | Tudorza Pressair | aclidinium bromide | PDR |
| Max dose for adults | 2.0 | actuations/day | 2 | actuations/day | PO, oral | Tudorza Pressair | aclidinium bromide | PDR |
| Max dose for geriatric | 0.8 | mg/day | 800 | mcg/day | PO, oral | Tudorza Pressair | aclidinium bromide | PDR |
| Max dose for geriatric | 2.0 | actuations/day | 2 | actuations/day | PO, oral | Tudorza Pressair | aclidinium bromide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1