DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD08895
Drug Name	Tofacitinib
Molecular Weight	312.3696
Molecular Formula	C16H20N6O
CAS Number	477600-75-2
SMILES	[H][C@@]1(C)CCN(C[C@]1([H])N(C)C1=NC=NC2=C1C=CN2)C(=O)CC#N
External Links
	DRUGBANK	DB08895
	PubChem Compound	9926791
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	1.808	-	1.808	-	MSDS, Tofacitinib Citrate

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Absorption	74.0	%	74	%	PO, oral;	DRUGBANK
Bioavailability	74.0	%	74	%	PO, oral;	DRUGBANK
T Max	0.75	h	0.5-1	h	PO, oral;	DRUGBANK
Clearance	0.35	L/h/kg	5.88	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	87.0	L	87.0	L	intravenous injection, IV;	DRUGBANK
Volume of Distribution	1.2	L/kg	1.24	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	3.0	h	~3	h		DRUGBANK
Toxicity LDLo	500.0	mg/kg	500.0	mg/kg	Rattus, Rat;	DRUGBANK
Eliminate Route	30.0	%	30	%	Unchanged drug;	DRUGBANK
Protein Binding	40.0	%	40	%		DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1