Basic Information
| Drug ID | DDPD08889 |
|
| Drug Name | Carfilzomib | |
| Molecular Weight | 719.9099 | |
| Molecular Formula | C40H57N5O7 | |
| CAS Number | 868540-17-4 | |
| SMILES | CC(C)C[C@H](NC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 | |
| External Links | ||
| DRUGBANK | DB08889 | |
| PubChem Compound | 11556711 | |
| PDR | 2563 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| pKa | 3.5 | - | 3.5 | - | FDA |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 379.0 | ng.h/ml | 379.0 | ng.h/ml | DRUGBANK | |
| C Max | 4232.0 | ng/ml | 4232 | ng/ml | DRUGBANK | |
| Clearance | 207.0 | L/h | 151 - 263 | L/h | Total clearance; | DRUGBANK | Clearance | 2.4 | L/h/kg | 39.5 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 28.0 | L | 28.0 | L | at steady state; | DRUGBANK | Volume of Distribution | 0.13 | L/kg | 0.13 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.0 | h | <=1 | h | intravenous injection, IV; | DRUGBANK | Half-life | 1.1 | h | 1.1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity MTD | 15.0 | mg/m2 | 15.0 | mg/m2 | DRUGBANK | |
| Protein Binding | 97.0 | % | 97 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 70.0 | mg/m2/dose | 70 | mg/m2/dose | intravenous injection, IV | Kyprolis | carfilzomib | PDR |
| Max dose for adults | 2.2 | m2 | 2.2 | m2 | skin/dermal | Kyprolis | carfilzomib | PDR |
| Max dose for adults | 154.0 | mg | 154 | mg | intravenous injection, IV | Kyprolis | carfilzomib | PDR |
| Max dose for geriatric | 70.0 | mg/m2/dose | 70 | mg/m2/dose | intravenous injection, IV | Kyprolis | carfilzomib | PDR |
| Max dose for geriatric | 2.2 | m2 | 2.2 | m2 | skin/dermal | Kyprolis | carfilzomib | PDR |
| Max dose for geriatric | 154.0 | mg | 154 | mg | intravenous injection, IV | Kyprolis | carfilzomib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1