Basic Information
| Drug ID | DDPD08883 |
|
| Drug Name | Perampanel | |
| Molecular Weight | 349.393 | |
| Molecular Formula | C23H15N3O | |
| CAS Number | 380917-97-5 | |
| SMILES | O=C1N(C=C(C=C1C1=CC=CC=C1C#N)C1=NC=CC=C1)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB08883 | |
| PubChem Compound | 9924495 | |
| PDR | 3449 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | 100 | % | PO, oral; | DRUGBANK |
| Clearance | 0.72 | L/h | 12.0 | ml/min | normal,healthy; patients; | DRUGBANK | Clearance | 0.006000 | L/h/kg | 0.1 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.4 | L/kg | 1.36 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 105.0 | h | ~105 | h | elimination half-life; | DRUGBANK | Half-life | 183.0 | h | 183 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 48.0 | % | 48 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 22.0 | % | 22 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 95.5 | % | 95-96 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 12.0 | mg/day | 12 | mg/day | PO, oral | Fycompa | perampanel | PDR |
| Max dose for adolescents | 12.0 | mg/day | 12 | mg/day | PO, oral | Fycompa | perampanel | PDR |
| Max dose for adults | 12.0 | mg/day | 12 | mg/day | PO, oral | Fycompa | perampanel | PDR |
| Max dose for geriatric | 12.0 | mg/day | 12 | mg/day | PO, oral | Fycompa | perampanel | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1