Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD08880 ...
Drug Name Teriflunomide
Molecular Weight 270.2073
Molecular Formula C12H9F3N2O2
CAS Number 163451-81-8
SMILES C\C(O)=C(/C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F
External Links
DRUGBANK DB08880
PubChem Compound 54684141
PDR 2614
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
T Max 2.5 h 1-4 h PO, oral; DRUGBANK
Clearance 0.0305 L/h 30.5 ml/h Total clearance; intravenous injection, IV; DRUGBANK
Clearance 0.000420 L/h/kg 0.007 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 11.0 L 11.0 L intravenous injection, IV; Single dose; DRUGBANK
Volume of Distribution 0.16 L/kg 0.16 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 444.0 h 18-19 day DRUGBANK
Half-life 350.0 h 350 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 37.5 % 37.5 % Faeces excretion; DRUGBANK
Eliminate Route 22.6 % 22.6 % Urinary excretion; DRUGBANK
Protein Binding 99.0 % >99 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 14.0 mg/day 14 mg/day PO, oral Aubagio teriflunomide PDR
Max dose for geriatric 14.0 mg/day 14 mg/day PO, oral Aubagio teriflunomide PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1